Oxy 80 is a high-strength, extended-release form of oxycodone. It is prescribed for severe, persistent pain requiring continuous opioid treatment when safer options are inadequate.
Medical benefits include:
- Long-lasting, around-the-clock relief of severe chronic pain
- Reduced pain intensity, potentially improving sleep, mobility and daily functioning
- More consistent pain control than repeatedly treating pain after it returns
Critical 80 mg warning
The 80 mg tablet is only for opioid-tolerant patients. For someone without established opioid tolerance, one tablet may cause fatal respiratory depression. It is not a starting dose or medication for occasional pain.
Swallow it whole—never crush, chew, dissolve, snort or inject it, as this can release a potentially fatal amount rapidly. Do not combine it with alcohol, alprazolam, clonazepam, morphine, hydromorphone, GHB or sleeping medications unless specifically managed by a prescriber. Oxycodone can cause dependence, overdose and life-threatening slowed breathing.



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